Exhibit 10.15


This amendment, dated 22 March 2011, is by and between Cytopherx, Inc. (“LICENSEE”) and the Regents of the University of Michigan (“MICHIGAN”).

WHEREAS, Nephrion, Inc., now doing business as Cytopherx, Inc. and MICHIGAN entered into a license agreement dated 16 October 2007(the “License Agreement”); and

WHEREAS, MICHIGAN and LICENSEE desire to modify certain provisions of the License Agreement as provided herein.

NOW THEREFORE, MICHIGAN and LICENSEE hereby agree as follows:

1. Existing Paragraph 1.6 shall be deleted in its entirety and replaced with the following:

1.6 “PATENT RIGHTS” means MICHIGAN’s legal rights under the patent laws of the United States or relevant foreign countries for all of the following:

(a) the following United States and foreign patent application(s),





United States    60/969,394
United States    12/201,576
United States    12/827,594
United States    12/827,601
United States    12/827,606
United States    12/827,609
Patent Cooperation Treaty    PCT/US08/74804
Australia    2008293431
Brazil    PI0816165-8
Canada    2,697,681
China    200880113549.4
Europe    08828222.3
Hong Kong    10109152.3
India    1411/DELNP/2010
Israel    204175
Japan    2010-523158
Korea    10-2010-7006729
Mexico    MX/a/2010/002351
New Zealand    583591

; any and all United States and foreign patents issuing from said patent applications; any and all divisionals and continuations claiming priority to one or more of said patent applications; and continuations-in-part of said patent applications, but only continuations-in-part that claim priority to one or more of said patent applications and to the extent that claims are directed to subject matter specifically described in said patent applications:

(b) claims in all patent applications and of the resulting patents, which are directed to subject matter specifically described as of the Effective Date in the MICHIGAN Office of Technology Transfer file 3718; and

(c) any reissued and reexamined patents, and extensions (including supplementary protection certificates or equivalents thereof), of the patents described in (a) and (b) above.

2. The Parties agree that LICENSEE has met milestones #1 and #2 in Paragraph 5.2 and wish to amend the remaining milestone as follows:

3) File PMA Application by Q4, 2014

3. MICHIGAN’S address in Article 13 shall be revised as follows:


The University of Michigan

Office of Technology Transfer

1600 Huron Parkway, 2nd Floor

Ann Arbor, MI 48109-2590

Attn: UM File #3718

4. Except as specifically modified and amended above, all other terms and conditions of the License Agreement remain unchanged and in effect and are hereby ratified and adopted as though fully set forth herein.

IN WITNESS WHEREOF, the parties have entered into this Amendment to the Amended Agreement as of the date and year first above-written.





/s/ Mark R. Morsfield


/s/ Kenneth J. Nisbet

Title:   Chief Financial Officer      Title:    Executive Director, UM Technology